| With the continuing discovery and exploitation of natural gas resource, the available range of natural gas is gradually enlarged. At the same time, the natural gas plays an important role in our country’s economic construction. The purification plant needs to deal with the high-sulfur natural gas which has higher H2S content. The large solution circulation, long technological process and utilities with high energy consumption are the characteristics of present situation. This article analyzes the energy consumption points and associated factors in desulfurization unit, and then from different angles such as process program optimization, the adoption of advanced energy-saving equipment, the recycle of recovered energy, the reduction of energy loss during technological process and so forth, proposes the following application and transformation measures, including heat pump, the split-flow technology of barren liquor and half barren liquor and plate-type heat exchanger which can be utilized in MDEA desulfurization unit. Meanwhile, the advantages and the application conditions of each energy conservation measure is elaborated. It is necessary to tap energy saving potential, which can create both good economic and environmental benefits.